Hryhorii is credited with the icon of Virgin Hodegetria with the prophets, which belongs to the best icons of this type. In the National Gallery of Bucharest (Romania), there is a similar Bosykovych icon "Our Lady of Hodegetria", 1522, which indicates that the author repeatedly turned to this iconography. At the end of the 15th and early 16th centuries, artists slightly departed from the canonical images, changing the modelling of faces and figures and bringing elements of ideal life into the icon. Thus conditional realism in the icon by Hryhorii Bosykovych is noticeable in the poetic interpretation of the female image, in the depiction of the angels over the Mother of God. On the light blue background stands the image of the Hodegetria, the silhouette of which is somewhat reduced, with an obvious striving for plastic volume. Light ochre carnation, optimistically courageous expression of the face indicate the influence of the new Renaissance style. The prophets placed on three sides of the icon are interpreted under the influence of the last century murals. To the right, at the upper part of the work, fragments of the palette have survived, showing how much of the pictorial layering was removed from the icon during the restoration. The icon of Virgin Hodegetria with the prophets is painted in a light and resonant colour scheme.