The composition, in terms of its stylistic features and execution, is delicate and subtle. The artist skilfully reproduces the classical forms of his era with brilliant originality and fills the canvas with exquisite colouring. He demonstrates a dazzling manner of rendering images with a loss of contours in dark shades, which gives his figures a tender appearance. The Virgin Mary holds Christ, who extends his left hand to bless the infant John the Baptist in the left part of the canvas. Saint John is already dressed in animal skins, which he will wear when preaching in the desert. Two angels stand behind him. This scene unfolds against the backdrop of a hill and a minimalistic landscape. The original painting by del Sarto showcases his increasingly mannerist elegance in colours, complex artificial composition, and elegantly refined poses that convey emotions with great immediacy. This work is similar to a slightly smaller composition by Andrea del Sarto, dated around 1517–19, preserved in the Wallace Collection in London.